A handful of works define the Vatican's collections for most visitors: Michelangelo's Sistine ceiling and Last Judgment, his Pietà, Raphael's School of Athens, the ancient Laocoön, and Bernini's bronze Baldacchino — spanning a Roman-era sculpture to 17th-century Baroque.
Are these the artworks displayed on the standard Vatican Museums route, or do some require special access?
All of them are on the standard route — the Sistine ceiling, the Pietà (in St. Peter's Basilica, not the Museums), the School of Athens and the Baldacchino are all visible on a normal ticketed visit, no special access needed.
Which of these works is easiest for visitors to walk past without realizing its significance?
The Laocoön, in the Museums' Octagonal Courtyard — a Roman-era sculpture that heavily influenced Michelangelo, but without a guide it's easy to treat as just another antique statue among many.
Is the Pietà technically part of the "Vatican Museums" collection?
No — it's inside St. Peter's Basilica itself, a separate (and free) visit from the Museums, even though both sit within Vatican City.