The collection grew out of 19th-century papal acquisitions and excavations, and sits near the start of the visitor route — easy to see without a big detour, and a genuine highlight for younger visitors who might otherwise flag during gallery after gallery of Renaissance painting.

The collection spans nine rooms, arranged roughly by theme rather than strict chronology — sarcophagi and funerary items cluster near the entrance, with a smaller display of Mesopotamian and Assyrian material further in that most visitors move past without stopping.