Vicino San Pietro (right by St. Peter's)

Steps from the Basilica and the Museums — ideal if you want to walk everywhere and start early, at a price premium for the location.

Prati

An elegant, mostly residential neighbourhood just north of the Vatican, with excellent metro connections and far more restaurant choice than the immediate Vatican area — a strong overall pick.

Ottaviano

One metro stop from the Vatican on Line A, generally the best value-for-money base, still walkable to the Museums entrance in 10–15 minutes.

Historic centre

20–25 minutes on foot (or a short bus/taxi ride) from the Vatican, but puts you in the middle of everything else in Rome — a good choice if the Vatican is a half-day trip within a longer stay.